Start with a good preparation
There are few resources as valuable to cancer researchers as tissue samples, the biospecimens that patients donate to aid in the search for cancer-related biomarkers. Harvesting and storing human tissue for research purposes is not new. However, it has become clear that the great majority of biospecimens stored in the world’s biorepositories may not be suited for the state-of-the-art genomics, proteomics, metabolomics, and the other bioanalytical technologies used today to search for cancerrelated biomarkers. The irreproducibility of many reported biomarkers is due at least in part, to the fact that the biospecimens utilized are often procured using different collection, processing and storage techniques.*
Such variability can lead to significant differences in biospecimen molecular integrity.
* International Approaches to Advancing Biospecimen Science. Helen M. More et all. Cancer Epidemiol Biomarkers Prev. May 2011; 20(5): 729-732
To overcome some of these difficulties
Milestone has developed the FlashFREEZE unit to standardize the biospecimen flash freezing processing step of biospecimen.
With FlashFREEZE it is now possible to run evidence-based biospecimen freezing protocols with the full documentation needed for QA purposes. FlashFREEZE combines the advantages of a state-of-the-art Stirling cooler, capable of reaching temperatures down to -80°C. FlashFREEZE eliminates the need of toxic reagents such as isopentane.
THE UNIQUE FEATURES OF FLASHFREEZE
- High flexibility: Standardized freezing at -80°C for all tissue types
- Fast: 1 hour 40 minutes to the final operating temperature of -80°C. Biospecimens are frozen in only 60-120 seconds
- Safe: HEPA cap filter
- Environmentally friendly: No standard compressor, no CFC
- Fully documented
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