Reagents & Accessories

For the environmentally-friendly histology laboratory

MILESTONE GREEN PRODUCTS

For the environmentally-friendly histology laboratory

FINEFIX - THE FORMALIN FREE FIXATIVE

FINEFIX - THE FORMALIN FREE FIXATIVE

The search for the ideal fixative is on...

The ideal fixative should present a low level of toxicity, produce optimal H&E, IHC and histochemical staining and allow recovery of DNA, RNA, and Protein for molecular analysis.

Good news! The search is over: FineFIX

FineFIX is a patented formalin-free, water-based concentrate. When diluted with ethanol, its formulation of low toxicity additives overcomes the drawbacks commonly associated with the use of pure ethanol or ethanol based fixatives, (e.g., significant tissue shrinkage, vacuolization and pyknotic nuclei). FineFIX also provides optimal preservation of tissue antigens, nuclear and cytoplasmic morphology and reduced lysis of red blood cells with preservation of the cytoplasmic membranes.


Available Tanks: 5L or 10L tank concentrate.

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FORMSAFE

FORMSAFE

High safety formalin prefilled container

In December 2013 the EU-REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) adopted a decision to reclassify formaldehyde as a Category 1B carcinogen and Category 2 mutagen under the EU CLP (Classification, Labeling and Packaging) Regulation.
This will mandate the replacement of formaldehyde with less dangerous alternatives and, when that is not possible, restricting its exposure using engineering and other controls.

FormSAFE provides an excellent alternative to traditional prefilled containers when personnel are concerned with formalin exposure during collection, transport and storage. A second stratified fluid component floats above the formalin phase and acts as a protective floating shield, which prevents fixative fumes from escaping from the container. This concept of a multi-layered liquid container allows safe handling both to the endoscopist at sampling and to the histologist when preparing the cassette. The endoscopist can easily detach the specimen from the tweezers by immersing them in the liquid without being exposed to formalin vapors. The histologist can open the container and pick up the specimen without being exposed to the fumes.


Available Packages: 21 boxes or 70 boxes of 50 containers each.

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JFC

JFC

HIGH PERFORMANCE XYLENE-FREE PROCESSING SOLUTION

The JFC Solution is an innovative, patented solution composed by a mixture of ethanol, isopropanol and a long chain hydrocarbon. Under the influence of microwaves, this solution becomes highly effective in the extraction of water and lipids from biological tissue, in a single step, without the need of further dehydration or clearing. The miscibility of the three components of the JFC Solution allows performing dehydration and clearing in a single step, representing a significant advantage over the conventional processing method. The action of the mixture can be explained by the polarity of the molecules.
In general, for an optimal extraction, the polarity of the solvent should be similar to that of the impurity you want to remove. In histoprocessing, such impurities are generally water and lipids. The isopropanol, a polar molecule, contributes to dehydration and also improves the extraction of non-polar fatty. Ethanol, also a polar molecule, primarily serves to dehydrate. The action of both alcohols will be highly efficient under the stimulation of microwaves. The third component of the JFC Solution, an organic solvent, is chemically inert, and not polar.


Available Tank: 5L.
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MILEGREEN

MILEGREEN

THE XYLENE SUBSTITUTE

MileGREEN is a solvent, consisting of iso-paraffins and replaces xylene both at the clearing and mounting process. Moreover it can be used for cleaning purposes for paraffin contaminated items, for example in the Milestone HistosMATE module. When heated this solution becomes highly effective in the extraction of lipids from biological tissue.

MileGREEN is an almost odorless, non-carcinogenic solvent and has the properties to solve fat and paraffin. MileGREEN’s formulation of low toxicity overcomes the drawbacks commonly associated with xylene, a hazardous product for the human nervous system. MileGREEN also provides optimal structural preservation of both the structure and the nuclear and cytoplasmic morphology of fat cells.


Available Tank: 5L.
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MoL-DECALCIFIER

MoL-DECALCIFIER

EDTA based decalcifying solution

For a faster decalcification time, the process with EDTA is best carried out at a pH value of 7.2-7.4. Milestone has developed an innovative, pure EDTA solution, based on a stoichiometric mixture of bibasic or tribasic EDTA to reach this pH value without the addition of an acid/base buffer. The combination of increased temperature, stirring and the MoL-DECALCIFIER, during the decalcification phase allows fixation, decalcification and processing of bone marrows within 48 hours.

Optimized Molecular Results

A presentation during the “First Symposium on Pre-analytic of Pathological Specimens - Berlin March 2013” reported the first results on H&E, IHC, FISH and molecular using the Milestone's decalcifying solution MoL-DECALCIFIER on bone marrow trephine biopsies.


MoL-DECALCIFIER unbuffered 10% EDTA: available in 5-liter tanks.

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MCC

MCC

OPTIMIZED CRYOEMBEDDING COMPOUND

The perfect cryoembedding composition for the PrestoCHILL system.

  • The MCC is a proprietary formulation of glycols and resins specifically developed for optimal support during cryotomy of dissected tissues down to -40°C.
  • The MCC is water soluble and doesn’t leave any residue on slides eliminating non specific background staining. The MCC compound will not dull microtome knives.


Available Package: 125 ml squeeze bottles, box of 12 bottles.

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SYNERGY KIT

SYNERGY KIT

KITS FOR PROCESSING AND EMBEDDING IN ONE STEP

The joint effort of Milestone and Klinipath created Synergy: a revolutionary Patented (n. EP 2 439 510 A1) method to automatically embed tissues as part of the processing protocols. This method is applied to Milestone’s rapid tissue processors: Pathos Delta and Logos.
Thanks to a dedicated rack and consumables, the same processor unit can achieve automatic embedding. All kinds of tissues and dimensions can be processed and embedded with this method.

SYNERGY CONSUMABLE PACKAGES

  • 1360 Molds (standard, biopsies or Needle biopsies)
  • 1400 Pads

Available in different packages to suit individual requirements

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VACUUM BAGS

VACUUM BAGS

FOR FORMALIN-FREE surgery suites

Stand-up vacuum-sealed bags for both TissueSAFE Plus and SealSAFE vacuum units. A professional barrier against infective agents, undesired smells and toxic formalin fumes! An innovative barrier against infective agents, undesired smells and toxic formalin fumes! A fraction of the space is necessary compared to stored standard containers. Milestone’s bags make storage and the tissue transport costs effective and safer.

  • A Dual thermal sealing ensures reliability in sealing the fixative in.
  • Vacuum sealing or auto dispensing of preset formalin ratios dispensing
  • Re-sealable up to four times, economic reuse for additional specimen access and archival
  • Made of dioxin-free plastic, Milestone’s bags grant their disposal to be environmental friendly.
  • Milestone’s vacuum systems and vacuum-sealed bags eliminate the risks of formalin handling.


Available in different sizes to suit individual requirements
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Catalog

Take a moment to consult our catalog to learn MILESTONE GREEN PRODUCTS, for the environmentally-friendly histology laboratory

GREEN PRODUCTS

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